Rx Vetoryl (trilostane) Capsules for Dogs
Vetoryl (trilostane) Capsules are used for the treatment of hyperadrenocorticism (Cushing's syndrome or disease) in dogs. This includes both pituitary-dependent and adrenal-dependent forms of the disease. Vetoryl is an adrenocortical suppressant and is FDA-approved for oral use in dogs only.
Directions:
Always provide the Client Information Sheet with the prescription.
The starting dose is 1.0-3.0 mg/lb (2.2-6.7 mg/kg) once daily, administered with food. Capsule combinations may be required depending on the dog’s weight.
Starting Dose Guidelines:
- 10–22 lb (4.5–10 kg): 30 mg once daily
- 22–44 lb (10–20 kg): 60 mg once daily
- 44–88 lb (20–40 kg): 120 mg (2 x 60 mg) once daily
- 88–132 lb (40–60 kg): 180 mg (3 x 60 mg) once daily
- Over 132 lb (60+ kg): Use appropriate capsule combinations
After 10–14 days of treatment, re-examine the dog and perform a 4–6 hour post-dosing ACTH stimulation test to determine further action.
Post-ACTH Cortisol Levels:
- <1.45 µg/dL: Stop treatment and restart at a lower dose
- 1.45–5.4 µg/dL: Continue current dose
- 5.4–9.1 µg/dL: Continue if signs are controlled, or increase dose if needed
- >9.1 µg/dL: Increase dose
Monitor closely after any dose change. If signs are not controlled throughout the day, split the daily dose into two and administer 12 hours apart. Long-term monitoring should occur at 30 days, 90 days, and every 3 months thereafter, including ACTH tests, physical exams, and bloodwork.
Cautions:
Do not use in dogs that are pregnant or have kidney or liver disease. Inform your veterinarian of all medications your dog is taking, including over-the-counter products.
In the case of overdose, symptomatic treatment for hypoadrenocorticism (e.g., corticosteroids, fluids) may be required.
Drug Interactions: Use ACE inhibitors with caution due to additive effects on aldosterone levels. Do not use potassium-sparing diuretics (e.g., spironolactone) with Vetoryl, as both may increase the risk of hyperkalemia.
View manufacturer and/or label information
This product requires a Valid prescription.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.